skin rash

Aloe vera


(In territories with significant traditional TRAMIL use)

  • Barbados : aloe
  • Marie-Galante Island : lalwé
  • Puerto Rico : sábila
  • Tobago : aloe
  • Venezuela : sábila

Significant uses found by the TRAMIL surveys

“crystal”, in cataplasm1

note: "crystal" is the term used in Puerto Rico to refer to the transparent, gelatinous gel found in the internal part of the leaf.

Recommandations
Preparation and posology
References

According to published and other information:

Use for asthma, colds, baldness, cuts, bounds and skin rashes is classified as REC, based on the significant traditional use documented inthe TRAMIL surveys, toxicity studies, scientific validation, and published scientific information.

Due to the health risks related to asthma, an initial medical evaluation is recommended.  The use of this plant remedy should be considered complementary to medical treatment.  There is no available information about its use for asthmatic crisis.

For topical application, strict hygiene measures should be observed in order to avoid contamination or additional infection.

Not for oral administration to  pregnant or lactating women or to children under 5 years of age.  The use of this resource should be avoided in cases of diabetes mellitus.

The gel can cause reactions of hypersensitivity.  It should not be used if it has turned a reddish color.

When cutting out the gelatinous part of the leaf, avoid contact with the yellow juice.  This juice can cause reactions of skin hypersensitivity or, if swallowed, it can have laxative effects.

Use for asthma or colds:

Peal the leaf and blend 15-30 grams (1-2 spoonfuls) of the “crystal” (gel, pulp, mesophyll) with 250 mL (1 cup) of water.  Drink 1 cup 3 times a day.

Prepare a decoction or infusion with 15-30 grams of gel in 250 mL (1 cup) of water.  For decoction, boil for at least 10 minutes in covered pot.  For infusion, add boiling water to 15-30 grams (1-2 spoonfuls) of gel, cover, and let cool.  Drink 1 cup 3 times a day.

For baldness, cuts, bounds and skin rashes:

Wash and peal the leaf, cut 15-30 grams (1-2 spoonfuls) of gel and apply to affected area of skin or scalp, twice a day.

1 BENEDETTI MD, 1994
Encuesta TRAMIL. Universidad de Puerto Rico, Mayagüez, Puerto Rico.

2 FAUJOUR A, MURREY D, CHELTENHAM-CORBIN B, CARRINGTON S, 2003
TRAMIL survey. enda-caribbean, IICA & UAG, Saint Thomas, Barbados.

3 DELAIGUE J, 2005
TRAMIL survey. UAG & PRDI, Tobago House of Assembly, Scarborough, Tobago.

4 YAMAGUCHI I, MEGA N, SANADA H, 1993
Components of the gel of Aloe vera (L.) Burm. f. Biosci Biotech Biochem57(8):1350-1352.

5 GOWDA DC, NEELISIDDAIAH B, ANJANEYALU YV, 1979
Structural studies of polysaccharides from Aloe vera. Carbohydr Res72:201-205.

6 MANDAL G, DAS A, 1980b
Structure of the glucomannan isolated from the leaves of Aloe barbadensis Miller. Carbohydr Res 87:249-256.

7 MANDAL G, GHOSH R, DAS A, 1984
Characterization of the polysaccharides of Aloe barbadensis Miller: part III. Structure of a acidic oligosaccharide. Indian J Chem Ser B22:890-893.

8 HAQ N, HANNAN A, 1981
Studies on glucogalactomannan from the leaves of Aloe vera Tourn. (ex Linn.). Bangladesh J Scient & Ind Res16:68-72.

9 HART LA, VAN DER BERG AJJ, KUIS L, VAN DIJK H, LABADIE RP, 1989
An anti-complementary polysaccharide with immunological adjuvant activity from the leaf parenchyma cells of Aloe vera. Planta Med 55(6):509-512.

10 McANALLEY BH, 1988
Process for preparation of Aloe products, produced thereby and composition thereof. Patent - USA: 4,735,935

11 MANNA S, McANALLEY BH, 1993
Determination of the position of the O acetyl group in a b(1®4) mannan (acemannan) from Aloe barbadensis Miller. Carbohydr Res 241:317-319.

12 YAMAGUCHI I, MEGA N, SANADA H, 1993
Components of the gel of Aloe vera (L.) Burm.F. Bioscience, Biotechnology, Biochemistry57:1350-1352.

13 MARY NY, CHRISTENSEN BV, BEAL JL, 1956
A paper chromatographic study of Aloe, aloin and cascara sagrada. J Am Pharm Assoc Sci Ed 45:229-232.

14 HOLDSWORTH DK, 1971
Chromones in Aloe species. Part I. Aloesin-A C-glucosyl-7-hydroxychromone. Planta Med 19:322-325.

15 PASZKIEWICZ-GADEK A, CHLABICZ J, GALASINSKI W, 1988
The influence of selected potential oncostatics of plant origin on the protein biosynthesis in vitro. Pol J Pharmacol Pharm 40(2):183-190.

16 RAUWALD H, 1987
New hydroxyaloins: the periodate-positive substance from cape aloes and cinnamoyl esters from Curacao aloes. Pharm Weekbl (Sci Ed) 9(4):215.

17 ZWAVING JH, ELEMA ET, 1976
A comparative investigation of two methods for the determination of 1,8-dihydroxyanthracene derivatives in vegetable drugs. Pharm Weekbl (Sci Ed) 111:1315.

18 WALLER GR, MANGIAFICO S, RITCHEY CR, 1978
A chemical investigation of Aloe barbadensis. Proc Okla Acad Sci58:69.

19 WALLER GR, MANGIAFICO S, RITCHEY CR, CUMBERLAND CD, 1978
Natural products from Aloe barbadensis Miller. Lloydia41:648A.

20 SUGA T, HIRATA T, 1983
The efficacy of the Aloe plants chemical constituents and biological activities. Cosmet Toiletries98(6):105-108.

21 MUKERJI B, 1953
The Indian pharmaceutical codex. Volume I - Indigenous drugs. New Delhi, India: Council of Scientific and Industrial Research.

22 MANDAL G, DAS A, 1980
Characterization of the polysaccharides of Aloe barbadensis Miller. part I. Structure of the D-galacatan isolated from Aloe barbadensis Miller. Carbohydr Res86:247-257.

23 MANDAL G, DAS A, 1980
Characterization of the polysaccharides of Aloe barbadensis Miller. part II. Structure of the glucomannan isolated from the leaves of Aloe barbadensis Miller. Carbohydr Res 87:249-256.

24 GUARDARRAMA I, HERNANDEZ M, DIAZ-ACOSTA A, CARBALLO A, 1993
Observaciones clínicas sobre el efecto delAloe barbadensis L. en el tratamiento de pacientes asmáticos. Estudio preliminar. Informe TRAMIL. Instituto Superior de Ciencias Médicas, Santa Clara, Cuba.TRAMIL VI, Basse Terre,Guadeloupe, UAG/enda-caribe.

25GUARDARRAMA I, TORRES ORLANDO, HERNANDEZ M, RUIZ MM, GOMEZ M, CLAVO Y, 1994
Prueba de hiperreactividad bronquial a la carbacolina en pacientes asmáticos tratados con Aloe barbadensis. Medicentro 10(1):93-101.

26 RAINE TJ, LONDON MD, GOLUCH L, HEGGERS JP, ROBSON MC, 1980
Antiprostagladins and antithromboxanes for treatment of frostbite. American College of Surgeons 1980 Surgical Forum31:557-559.

27MARTINEZ MJ, BETANCOURT J, ALONSO N, 1996
Ausencia de actividad antimicrobiana de un extracto acuoso liofilizado de Aloe vera (sábila). Rev Cubana Plantas Med 1(3):18-20.

28 GOTTSHALL RY, LUCAS E, LICKFELDT A, ROBERTS J, 1949
The occurrence of antibacterial substances active against Mycobacterium tuberculosis in seed plants. J Clin Invest 28:920-923.

29 CACERES A, GIRON L, ALVARADO SR, TORRES MF, 1987
Screening of antimicrobial activity of plants popularly used in Guatemala for the treatment of dermatomucosal diseases. J Ethnopharmacol20(3):223-237.

30 BUNYAPRAPHATSARA N, JIRAKULCAIWONG S, THIRAWARAPAN S, MANONUKUL J, 1996
The efficacy of Aloe vera cream in the treatment of first, second and third degree burns in mice. Phytomedicine2(3):247-251.

31 ROWE TD, LOVELL BK, PARKS LM, 1941
Further observations on the use of Aloe vera leaf in the treatment of third degree X-ray reactions. J Am Pharm Assoc Sci Ed30:266-269.

32 DAVIS RH, LEITNER MG, RUSSO JM, BYRNE ME, 1989
Wound healing. Oral and topical activity of Aloe vera. J Am Podiatr Med Assoc 79(11):559-562.

33 DAVIS RH, DONATO J, HARTMAN G, HAAS R, 1994
Anti-inflammatory and wound healing activity of a growth substance in Aloe vera. J Am Podiatr Med Assoc84(2):77-81.

34 DAVIS RH, AGNEW PS, SHAPIRO E, 1986
Antiarthritic activity of anthraquinones found in Aloe for podiatric medicine. J Am Podiatr Med Assoc76:61-66.

35 MOHSIN A, SHAH AH, AL-YAHYA MA, TARIQ M, TANIRA MO, AGEEL AM, 1989
Analgesic antipyretic activity and phytochemical screening of some plants used in traditional Arab system of medicine. Fitoterapia 60(2):174-177.

36FURONES JA, MORON FJ, PINEDO Z, 1996
Acción analgésica de un extracto acuoso liofilizado de Aloe vera L. en ratones. Rev Cubana Plantas Med 1(2):15-17.

37 STRICKLAND FM, PELLEY RP, KRIPKE ML, 1994
Prevention of ultraviolet radiation-induced suppression of contact and delayed hypersensitivity by Aloe barbadensis gel extracts. J Invest Dermatol102(2):197-204.

38 ROMAN-RAMOS R, FLORES-SAENZ JL, PARTIDA-HERNANDEZ G, LARA-LEMUS A, ALARCON-AGUILAR F, 1991
Experimental study of hypoglycemic activity of some antidiabetic plants. Arch Invest Med22(1):87-93.

39 DAVIS RH, LEITNER MG, RUSSO JM, 1987
Topical anti-inflammatory activity of Aloe vera as measured by ear swelling. J Am Podiatr Med Assoc 77(11):610-612.

40 DAVIS RH, LEITNER MG, RUSSO JM, 1988
Aloe vera. A natural approach for treating wounds, edema and pain in diabetes. J Am Podiatr Med Assoc78(2):60-68.

41 DAVIS RH, KABBANI JM, MARO NP, 1986
Wound healing and antiinflammatory activity of Aloe vera. Proceedings of the Pennsylvania Academy of Sciences60:79.

42 DAVIS RH, LEITNER MG, RUSSO JM, MARO NP, 1987c
Biological activity of Aloe vera. Med Sci Res15:235.

43 RODRIGUEZ-BIGAS M, CRUZ NI, SUÁREZ A, 1988
Comparative evaluation of Aloe vera in the management of burn wounds in guinea pigs. Plast Reconstr Surg81:386-389.

44 KIVETT WF, 1989
Aloe vera for burns. Plastic and Reconstructive Surgery 83:195.

45 CARBAJAL D, CASACO A, ARRUZAZABALA L, GONZALEZ R, FUENTES V, 1991
Pharmacological screening of plant decoctions commonly used in Cuban folk medicine. J Ethnopharmacol33(1/2):21-24.

46 DAVIS RH, DI DONATO JJ, JOHNSON RW, STEWART CB, 1994
Aloe vera, hydrocortisone, and sterol influence on wound tensile strength and anti-inflammation. J Am Podiatr Med Assoc84.(12):614-621.

47 LUSHBAUGH CC, HALE DB, 1953
Experimental acute radiodermatitis following beta irradiation. V. Histopathological study of the mode of action of therapy with Aloe vera. Cancer 6:690-698.

48 ROVATTI B, BRENNAN RJ, 1959
Experimental thermal burns. Induct Med Surg 28:364.

49 NORTHWAY RB, 1975
Experimental use of Aloe vera extract in clinical practice. Vet Med Small Animal Clinic70:80.

50 COBBLE HH, 1975
Stabilized Aloe vera gel. Patent - USA: 3,892,853.

51 FULTON JE, 1990
The stimulation of postdermabrasion wound healing with stabilized Aloe vera gel-polyethylene oxide dressing. J Dermatol Surg Oncol16(5):460-467.

52 YAGI A, SHIDA T, NISHIMURA H, 1987
Effect of amino acids in Aloe extract on phagocytosis by peripheral neutrophil in adult bronchial asthma. Jap J Allergol36(12):1094-1101.

53 KAVOUSSI H, KAVOUSSI HP, 1993
Saturated solution of purified sodium chloride in purified Aloe vera for inducing and stimulating hair growth and for decreasing hair loss. Patent - USA: 5,215,760.

54LEONJE, ROSALES V, ROSALES RA, PAVON V, 1999
Actividad antiinflamatoria y cicatrizante del ungüento rectal de Aloe vera L (sábila). Rev Cubana Plantas Med 4(3):106-109.

55 VISUTHIKOSOL V, CHOWCHUEN B, SUKWANARAT Y, SRIURAIRATANA S, BOONPUCKNAVIG V, 1995
Effect of Aloe vera gel to healing of burn wound a clinical and histologic study. J Med Assoc Thai 78(8):403-409.

56 CREWE JE, 1939
Aloes in the treatment of burns and scalds. Minnesota Med22:538-539.

57 SYED T, AHMAD S, HOLT A, AHMAD S, AHMAD S, AFZAL M, 1996
Management of psoriasis with Aloe vera extract in a hydrophilic cream: a placebo-controlled, double-blind study. Trop Med Int Health 1(4):505-509.

58 SYDISKIA RJ, OWEN DG, 1987
Aloe emodin and other anthraquinones and anthraquinone-like compounds from plants virucidal against Herpes simplex viruses. Patent - USA: 4,670,265.

59RAMOS A, EDREIRA AYMEE, VILLESCUSA A, VIZOZO A, MARTINEZ MJ, 1996
Evaluación genotóxica de un extracto acuoso de Aloe vera L. Rev Cubana Plantas Med 1(2):18-23.

60 VIZOSO A, RAMOS A, GARCIA A, PILOTO J, PAVON V, 2000
Estudio genotóxico in vitro e in vivo del extracto fluido de Cassia grandis L. y el gel de Aloe vera L. Rev Cubana Plantas Med 5(3):91-96.

61 DHAR ML, DHAR MM, DHAWAN B, MEHROTRA B, RAY C, 1968
Screening of Indian plants for biological activity. Part I. Indian J Exp Biol6:232-247.

62 BHAKUNI D, DHAR ML, DHAR MM, DHAWAN BN, GUPTA B, SRIMALI RC, 1971
Screening of Indian plants for biological activity. Part III. Indian J Exp Biol9:91.

63 SHAH AH, QURESHI S, TARIQU M, AGEEL AM, 1989
Toxicity studies on six plants used in the traditional Arab system of medicine. Phytother Res3(1):25-29.

64 YOKEL R, OGZEWALLA C, 1981
Effects of plants ingestion in rats determined by the conditioned taste aversion procedure. Toxicon19(2):223-232.

65 PRAKASH A, MATHUR R, 1976
Screening of Indian plant for antifertility activity. Indian J Exp Biol 14:623-626.

66 SETHI N, NATH D, SING R, 1989
Teratological evaluation of some commonly used indigenous antifertility plants in rats. Int J Crude Drug Res27(2):118-120.

67 MORROW DM, RAPAPORT MJ, STRICK RA, 1980
Hypersensitivity to Aloe. Archives of Dermatology 116:1064-1065.

68 PARRA AL, YHEBRA RS, SARDINAS IG, BUELA LI, 2001
Comparative study of the assay of Artemia salina L. and the estimate of the medium lethal dose (LD50 value) in mice, to determine oral acute toxicity of plant extracts. Phytomedicine 8(5):395-400.

69 Zambrano LE, 2007
Encuesta TRAMIL en Guareguare, Miranda. UCV, Caracas, Venezuela.

70 BALZ E, BOYER A, BURAUD M, 2007
Enquête TRAMIL à Marie-Galante. U. Bordeaux 3, U. Paris XI Chatenay-Malabry, UAG, Guadeloupe.

Momordica charantia


(In territories with significant traditional TRAMIL use)

  • Antigua : maiden blush
  • Barbados : cerasee
  • Costa Rica : sorosí
  • Dominica : kokouli
  • Dominican Republic : cundeamor
  • Guatemala : sorosí
  • Honduras : calaica
  • Haiti : asorosi
  • Puerto Rico : cundeamor
  • Tobago : corailee
  • Tobago : sorrow seed
  • Tobago : popololo
  • Venezuela : cundeamor

Significant uses found by the TRAMIL surveys

  leaf and stem, bath and cataplasm7,13

Recommandations
Preparation and posology
References

According to published and other information:

Use for furuncles and common cold is classified as REC, based on the significant traditional use documented in the TRAMIL surveys, toxicity studies and available published scientific information.

Use for dry skin conditions, itching, lice (pediculosis) and burns is classified as REC, based on the significant traditional use (OMS/WHO)4 documented in the TRAMIL surveys.

For topical application, strict hygienic measures should be observed in order to avoid contamination or additional infection.

Should there be a notable worsening of the patient’s condition, or should furuncles last more than 5 days, seek medical attention.

Do not take orally during pregnancy due to risk of abortion.

Not for use during lactation or by children under 3 years old.

For skin conditions:

Wash the aerial parts of the plant thoroughly and crush them.  Apply 30 grams (a handful) of vegetal material on the affected area of skin 3 times a day.

For common cold:

There is no available information establishing a means of preparation and dosage other than that referred to by traditional use.

1 CHARLES C, 1988 TRAMIL survey. Movement for Cultural Awareness MCA, Roseau, Dominica.

2 WENIGER B, ROUZIER M, 1986 Enquête TRAMIL. Service Oecuménique d'Entraide SOE, Port au Prince, Haïti.

3 LAGOS-WITTE S, 1988-1995 Encuestas TRAMIL. Laboratorio de Histología Vegetal y Etnobotánica, Departamento de Biología, Universidad Nacional Autónoma de Honduras UNAH, Tegucigalpa, Honduras.

4 GERMOSEN-ROBINEAU L, GERONIMO M, AMPARO C, 1984 Encuesta TRAMIL. enda-caribe, Santo Domingo, Rep. Dominicana.

5 WENIGER B, 1987-88 Encuesta TRAMIL. enda-caribe, Santo Domingo, Rep. Dominicana.

6 Castillo D, Rodriguez S, de los Santos C, Belen A, 2003 Encuesta TRAMIL (Zambrana, Cotuí). Dep. de Botánica, Jardín BotánicoNacional, Santo Domingo, República Dominicana.

7 Castillo D, Rodriguez S, de los Santos C, Belen A, 2003 Encuesta TRAMIL (region Este). Dep. de Botánica, Jardín BotánicoNacional, Santo Domingo, República Dominicana.

8 DELENS M, 1990 Encuesta TRAMIL en Barlovento, Edo. Miranda de Venezuela. Centro al Servicio de la Acción Popular CESAP, Caracas, Venezuela.

9 GIRON L, 1988 Encuesta TRAMIL (Costa atlántica). Centro Mesoamericano de Tecnología CEMAT, Guatemala.

10 O'REILLY A, 1992 TRAMIL survey. Chemistry & Food Technology Division, Ministry of Agriculture, Dunbars, Antigua & Barbuda.

11 OCAMPO R, 1988 Encuesta TRAMIL (Costa atlántica), Instituto de Desarrollo Agrario, Universidad de Costa Rica, San José, Costa Rica.

12 FAUJOUR A, MURREY D, CHELTENHAM-CORBIN B, CARRINGTON S, 2003 TRAMIL survey. IICA & UAG, Saint Thomas, Barbados.

13 BENEDETTI MD, 1994 Encuesta TRAMIL. Universidad de Puerto Rico, Mayagüez, Puerto Rico.

14 WHO, 1991 Pautas para la evaluación de medicamentos herbarios WHO/TRM/91.4 (original inglés). Programa de Medicina Tradicional, OMS, Ginebra, Suiza.

15 WENIGER B, SAVARY H, DAGUIHL R, 1984 Tri phytochimique de plantes de la liste TRAMIL. Laboratoire de chimie des substances naturelles, Faculté de médecine et de pharmacie, Université d'Etat d'Haïti, Port au Prince, Haïti.

16 HERRERA J, 1990 Determinación de actividades biológicas de vegetales utilizados en medicina tradicional. Informe TRAMIL. Dep. de Farmacología, Facultad de Salud, Universidad del Valle, Cali, Colombia.

17 DUKE JA, ATCHLEY AA, 1986 Handbook of proximate analysis tables of higher plants. Boca Raton, USA: CRC Press. p110.

18 YASUDA M, IWAMOTO M, OKABE H, YAMAUCHI T, 1984 Structures of momordicines I, II and III, the bitter principles in the leaves and vines of Momordica charantia. Chem Pharm Bull 32(5):2044-2047.

19 DHALLA NS, GUPTA KC, SASTRY MS, MALHOTRA CL, 1961 Chemical composition of the fruit of Momordica charantia. Indian J Pharmacy 23:128-130.

20 KANNA B, 1976 Insulin from Momordica charantia. Patent-Japan Kokai.

21 NG TB, YEUNG HW, 1984 Bioactive constituents of Cucurbitaceae plants with special emphasis on Momordica charantia and Trichosanthes kirilowii. Seoul, Korea: Proc. 5th. Symposium Medicinal Plants and Spices.

22 KHANNA P, MOHAN S, 1973 Isolation and identification of diosgenin and sterols from fruits and in vitro cultures ofMomordica charantia. Indian J Exp Biol11:58-60.

23 OKABE H, MIYAHARA K, YAMAGUCHI T, MIYAHARA K, KAWASAKI T, 1980 Studies on the constituents ofMomordica charantia L. I: Isolation and characterization of momordicosides A and B, glycosides of a pentahydroxy-cucurbitane triterpene. Chem Pharm Bull28(9):2753-2762.

24 RODRIGUEZ DB, RAYMUNDO LC, TUNG-CHING LEE, SIMPSON KL, CHICHESTER CO, 1976 Carotenoid pigment changes in ripening Momordica charantia fruits. Ann Bot (London)40:615-624.

25 LIN JY, HOU MJ, CHEN YC, 1978 Isolation of toxic and non-toxic lectins from the bitter pear melon (Momordica charantia). Toxicon16:653.

26 IYER RI, NAGAR PK, SIRCAR PK, 1981 Endogenous cytokinins in seeds of bittergourd Momordica charantia. Indian J Exp Biol19:766-767.

27 WONG CM, YEUNG HW, NG TB, 1985 Screening of Trichosanthes kirilowii,Momordica charantia andCucurbita maxima (family Cucurbitaceae) for compounds with antilipolytic activity. J Ethnopharmacol 13(3):313-321.

28 YEUNG HW, LI WW, FENG Z, BARBIERI L, STIRPE F, 1988 Trichosanthin, alpha-momorcharin and beta-momorcharin: Identity of abortifacient and ribosome-inactivating protein. Int J Peptide Protein Res 31(3):265-268.

29 MIYAHARA Y, OKABE H, YAMAUCHI T, 1981 Studies on the constituents ofMomordica charantia L. II: Isolation and characterization of minor seed glycosides, momordicosides C, D and E. Chem Pharm Bull29(6):1561-1566.

30 SAUVAIN M, KODJOED JF, BERGRAVE SJ, BONNEVIE O, DEDET JP, 1986 Plantes fébrifuges en médecine traditionnelle en Haïti et en République Dominicaine et thérapie du paludisme. Rapport TRAMIL: ORSTOM, Cayenne, Guyane Française.

31 MORETTI C, 1989 Determinación de la actividad antimalárica de plantas utilizadas por la medicina tradicional (Momordica charantia). TRAMIL IV, Tela, Honduras, UNAH/enda-caribe.

32 CACERES A, JAUREGUI E, HERRERA D, LOGEMANN H, 1991 Plants used in Guatemala for the treatment of dermatomucosal infections. 1: Screening of 38 plant extracts for anticandidal activity. J Ethnopharmacol 33(3):277-283.

33 HEAL R, ROGERS E, WALLACE RT, STARNES O, 1950 A survey of plants for insecticidal activity. Lloydia13(2):89-162.

34 OGUNLANA EO, RAMSTAD E, 1975 Investigation into the antibacterial activities of local plants. Planta Med27(4):354-360.

35 HUSSAIN HSN, DEENI YY, 1991 Plants in Kano ethnomedicine; screening for antimicrobial activity and alkaloids. Int J Pharmacol29(1):51-56.

36 MANEELRT S, SATTHAMPONGSA A, 1978 Antimicrobial activity ofMomordica charantia. Undergraduate special project report. Bangkok, Thailand: Mahidol University. Faculty of Pharmacy.

37 LAL J, CHANDRA S, RAVIPRAKASH V, SABIR M, 1976 In vitro anthelmintic action of some indigenous medicinal plants on Ascardia galli worms. Indian J Physiol Pharmacol20(2):64-68.

38 BISWAS AR, RAMASWAMY S, BAPNA JS, 1991 Analgesic effect ofMomordica charantia seed extract in mice and rats. J Ethnopharmacol31(1):115-118.

39 MOKKHASMIT M, SAWASDIMONGKOL K, SATRAWAHA P, 1971 Study on toxicity of Thai medicinal plants. Bull Dept Med Sci 12(1/2):36-65.

40 GONZALEZ A, ALFONSO H, 1990 Evaluación de la toxicidad dérmica deMomordica charantia L.,Foeniculum vulgare Mill yCassia occidentalis L. en cobayos. Informe TRAMIL. Centro Nacional de Salud Animal, La Habana, Cuba.

41 GONZALEZ A, ALFONSO H, 1990 Evaluación de la toxicidad dérmica deMomordica charantia L. yCassia occidentalis L. en conejos. Informe TRAMIL. Centro Nacional de Salud Animal, La Habana, Cuba.

42 TABORA O, 1986 Estudio de toxicidad aguda en ratones de la fracción hipoglucemiante deMomordica charantia (Cucurbitaceae). Tegucigalpa, Honduras: IV Semana Científica Universidad Nacional Autónoma de Honduras UNAH.

43 SAKSENA SK, 1971 Study of antifertility activity of the leaves ofMomordica (karela). Indian J Physiol Pharmacol15(2):79-80.

44 PRAKASH AO, MATHUR R, 1976 Screening of Indian plants for antifertility activity. Indian J Exp Biol14(5):623-626. 

45 SHARMA VN, SOGANI RK, ARORA RB, 1960 Some observations on hypoglycemic activity of Momordica charantia. Indian J Med Res48(4):471-477.

46 DIXIT VP, KHANNA P, BHARGAVA SK, 1978 Effects ofMomordica charantia fruit extract on the testicular function of dog. Planta Med34(3):280-286.

47 KOENTJORO-SOEHADI T, SANTA I, 1982 Perspectives of male contraception with regards to Indonesian traditional drugs. Bali, Indonesia: 2nd National Congress of Indonesian Society of Andrology.

48 KHAN AH, BURNEY A, 1962 A preliminary study of the hypoglycemic properties of indigenous plants. Pakistan J Med Res2:100-116.

49 WEST M, SIDRAK G, STREET S, 1971 The anti-growth properties of extracts from Momordica charantia. West Indian Med J20(1):25-34.

50 NG T, 1988 Effects of momorcharins on ovarian response to gonadotropin induced superovulation in mice. Int J Fertil33(2):123-128.

51 DELAIGUE J, 2005 TRAMIL survey. UAG & PRDI, Tobago House of Assembly, Scarborough, Tobago.