colics | TRAMIL

	Ambrosia peruviana (In territories with significant traditional TRAMIL use) Dominican Republic : artamisa Honduras : altamisa Panama : altamisa Significant uses found by the TRAMIL surveys fresh leaf and stem, infusion, orally¹	Recommandations Preparation and posology References	According to available information: Use for colic, stomach pain and headache is classified as REC, based on the significant traditional use (OMS/WHO)⁴ documented in the TRAMIL surveys. Not for use during pregnancy, during lactation or by children under 5 years old. The pollen deposited on the stem and leaves may cause reactions of hypersensitivity. Should there be a notable worsening of the patient’s condition, or should the colic or stomach pain last more than 3 days, seek medical attention.		Due to the presence of allergenic pollen in the stem and leaves, wash vegetal material before use. For colic, stomach pain and headache: There is no available information establishing a means of preparation and dosage other than that referred to by traditional use.	1 LAGOS-WITTE S, 1988-89, 1996 Encuesta TRAMIL. Laboratorio de Histología Vegetal y Etnobotánica, Departamento de Biología, Universidad Nacional Autónoma de Honduras UNAH, Tegucigalpa, Honduras. 2 GERMOSEN-ROBINEAU L, GERONIMO M, AMPARO C, 1984 Encuesta TRAMIL. enda-caribe, Santo Domingo, Rep. Dominicana. 3 SOLIS P, CORREA M, GUPTA M, 1995 Encuesta TRAMIL (Comunidades afro-caribeñas). Centro de Investigaciones Farmacognósticas de la Flora Panameña CIFLORPAN, Facultad de Farmacia, Universidad de Panamá, Panamá, Panamá. 4 WHO, 1991 Guidelines for the assessment of herbal medicines. WHO/TRM/91.4. Programme on Traditional Medicines, WHO, Geneva, Switzerland. 5 Solis PN, VAsquez Y, Ayala H, Gupta MP, 2002 Informe de validación de algunas plantas tramil. Informe TRAMIL. Centro de Investigaciones Farmacognósticas de la Flora Panameña CIFLORPAN, Facultad de Farmacia, Universidad de Panamá, Panamá, Panamá. 6 GOLDSBY G, BURKE B, 1987 Sesquiterpene lactones and a sesquiterpene diol from Jamaican Ambrosia peruviana. Phytochemistry26(4):1059-1063. 7 HERZ W, ANDERSON G, GIBAJA S, RAULAIS D, 1969 Sesquiterpene lactones of some Ambrosia species. Phytochemistry 8:877-881. 8 SOUZA BRITO A, 1995 Toxicidad aguda - dosis repetidas. Trabajos TRAMIL. Dep. de Fisiología y Biofísica, Universidad de Campinas, Campinas, Brasil. 9 BUZNEGO MT, LLANIO M, FERNANDEZ M, LEON N, ACEVEDO M, PEREZ H, 1998 Perfil neurofarmacológico de la Ambrosia paniculata (Willd) O.E. Schulz (Artemisa). Rev Cuba Plantas Med 3(1):42-45. 10 PAZOS L, COTO T, CAIZA F, 2009 Irritación dérmica, piel lesionada en conejos, hoja fresca, de Ambrosia peruviana. Informe TRAMIL. Laboratorio de Ensayos Biológicos, LEBi, Universidad de Costa Rica, San Pedro, Costa Rica. 11PAZOS L, COTO T, CAIZA F, 2009 Irritación dérmica, piel lesionada en conejos, hoja macerada en alcohol 94%, de Ambrosia peruviana. Informe TRAMIL. Laboratorio de Ensayos Biológicos, LEBi, Universidad de Costa Rica, San Pedro, Costa Rica.
	Citrus aurantium (In territories with significant traditional TRAMIL use) Quintana Roo : naranja agria Quintana Roo : naranja de babor Cuba : naranja agria Cuba : naranja de babor Dominican Republic : naranja agria, naranja de babor Grenada : sour orange Haiti : zowanj gospo Haiti : zowanj si Martinique : zowanj anmè Martinique : oranger amer Puerto Rico : naranja agria Puerto Rico : naranja de babor Significant uses found by the TRAMIL surveys leaf, decoction or infusion, orally¹	Recommandations Preparation and posology References	According to published and other information: Use for colic, conjunctivitis, headache, fever, flu, intestinal parasites and cough is classified as REC, based on the significant traditional use (OMS/WHO)⁴ documented in the TRAMIL surveys. In every application in the eyes, strict hygiene measures should be observed in order to avoid contamination or additional infection. Additionally, contact with any substances that may be irritating to the conjunctiva should be avoided. There exists the risk of increasing irritation due to the application of Citrus spp juice. Should there be a notable worsening of the patient’s condition, or should fever last more than 2 days, or should conjunctivitis or headache last more than 3 days, seek medical attention. Use for diarrhea and flatulence is classified as REC, based on the significant traditional use documented in the TRAMIL surveys, and on available published scientific information. In the case of diarrhea, the use of this resource can be considered complementary to oral re-hydration therapy. Should there be a notable worsening of the patient’s condition, or should diarrhea last more than 3 days in adult, or 2 days in children, seek medical attention. Due to the risk of interaction with cyclosporin, ingestion of the fruit decoction should be avoided by anyone taking this medicine. The essential oil of the plant can cause reactions of hypersensitivity.		The fruit and the juice of Citrus aurantium are widely used for human consumption and the peel as an industrial source of essential oil. For colic, headache, fever, flu: Prepare a decoction or infusion with 10-15 grams (3-5 tender leaves) in 1/2 liter (2 cups) of water. For decoction, boil for at least 10 minutes in a covered pot; for infusion, add boiling water to 3-5 tender leaves, cover and leave to cool down. Drink lukewarm, 1 cup 3 times a day¹. For fever: Prepare a decoction with 1-2 teaspoonfuls (5-10 grams) of fruit peel in 250 mL (1 cup) of water, boil for at least 10 minutes in a covered pot. Filter, cool down and drink 1 cup 3 times a day³³. For flatulence: Prepare an infusion, adding 1 liter (4 cups) of boiling water to the peel of half a fruit. Cover the pot, let it settle for 5-10 minutes and filter. Drink 1 cup as needed⁵. For intestinal parasites: Prepare a decoction with 8-18 tender leaves in 1/2 liter (2 cups) of water. Boil for at least 10 minutes in a covered pot. Leave it to cool down, sweeten with honey and drink lukewarm, 1 cup twice a day¹. For conjunctivitis, diarrhea, flu, cough (juice): There is no available information establishing a means of preparation and dosage other than that referred to by traditional use.	1 MENDEZ M, MEDINA ML, DURAN R, 1996 Encuesta TRAMIL. Unidad de recursos naturales, Centro de Investigación Científica de Yucatán CICY, Mérida, México. 2 WENIGER B, ROUZIER M, 1986 Enquête TRAMIL. Service Oecuménique d'Entraide SOE, Port au Prince, Haïti. 3 WENIGER B, 1987-88 Encuesta TRAMIL. enda-caribe, Santo Domingo, Rep. Dominicana. 4 GERMOSEN-ROBINEAU L, GERONIMO M, AMPARO C, 1984 Encuesta TRAMIL. enda-caribe, Santo Domingo, Rep. Dominicana. 5 MARCELLE G, 1996 TRAMIL survey. Produce chemist laboratory, Ministry of Agriculture, St George's, Grenada. 6 BENEDETTI MD, 1994 Encuesta TRAMIL. Universidad de Puerto Rico, Mayagüez, Puerto Rico. 7 OMS/WHO, 1991 Pautas para la evaluación de medicamentos herbarios WHO/TRM/91.4 (original inglés). Programa de Medicina Tradicional, OMS, Ginebra, Suiza. 8 LIN Z, HUA Y, GU Y, 1986 The chemical constituents of the essential oil from the flowers, leaves and peels of Citrus aurantium. Chih Wu Hsueh Pao 28(6):635-640. 9 RIO JAD, BENAVENTE O, CASTILLO J, BORREGO F, 1992 Neodiosmin, a flavone glycoside of Citrus aurantium. Phytochemistry 31(2):723-724. 10 BENNETT RD, MIYAKE M, OZAKI Y, HASEGAWA S, 1991 Limonoid glucosides in Citrus aurantium.Phytochemistry 30(11):3803-3805. 11 WIDMER WW, 1991 Improvements in the quantitation of limonin in Citrus juice by reversed-phase high-performance liquid chromatography. J Agric Food Chem 39(8):1472-1476. 12 HERMAN Z, FONG CH, OU P, HASEGAWA S, 1990 Limonoid glucosides in orange juices by HPLC. J Agric Food Chem 38(9):1860-1861. 13 HOSODA K, NOGUCHI M, KANAYA T, HIGUCHI M,1990 Studies on the preparation and evaluation of Kijitsu, the immature citrus fruits. III. Relation between diameter of Kijitsu and synephrine content. Yakugaku Zasshi 110(1):82-84. 14 BEZANGER-BEAUQUESNE L, PINKAS M, TORCK M, 1986 Les plantes dans la thérapeutique moderne. 2 éd. Paris, France: Ed. Maloine. 15 WAGNER H, BLADT S, MUNZING-VASITIAN K, 1975 Thin-layer chromatography of bitter principle drugs. Pharm-Ztg 120:1262. 16 DUKE JA, ATCHLEY AA, 1986 Handbook of proximate analysis tables of higher plants. Boca Raton, USA: CRC Press, p45. 17 AVIRUTANT W, PONGPAL A, 1983 The antimicrobial activity of some Thai flowers and plants. Mahidol Univ J Pharm Sci 10(3):81-86. 18 CACERES A, GIRON LM, ALVARADO SR, TORRES MF, 1987 Screening of antimicrobial activity of plants popularly used in Guatemala for the treatment of dermatomucosal diseases. J Ethnopharmacol 20(3):223-237. 19 KIM DH, SONG MJ, BAE EA, HAN MJ, 2000 Inhibitory effect of herbal medicines on rotavirus infectivity. Biol Pharm Bull 23(3):356-358. 20 SANKAWA U, 1980 Screening of bioactive compounds in oriental medicinal drugs. Korean J Pharmacog 11:125-132. 21 KINOSHITA T, SAMESHIMA M, SANKAWA U, 1979 Isolation of a sympathomimetic substance from Chinese medicinal drugs originated from Citrus sp. Shoyakugaku Zassmi 33:146-149. 22 FORSTER HB, NIKLAS H, LUTZ S, 1980 Antispasmodic effects of some medicinal plants. Planta Med 40(4):309-319. 23 YOO JS, JUNG JS, LEE TH, SON KH, SUH HW, SONG DK, KIM YH, 1995 Inhibitory effects of extracts from traditional herbal drugs on 5-hydroxytryptophan-induced diarrhea in mice. Korean J Pharmacog 26(4):355-359. 24 IWAMA H, AMAGAYA S, OGIHARA Y, 1986 Effects of five kampohozais on the mitogenic activity of lipopolysaccharide, concanavalin A, phorbol myristate acetate and phytohemagglutinin in vivo. J Ethnopharmacol 18(2):193-204. 25 HIRANO H, TAKASE H, YAMAMOTO K, YANASE T, ABE K, SAITO Y, 1997 The anti-ulcer effects of Aurantii Fructus Immaturus, Aurantii Fructus and the principles in Aurantii Fructus Immaturus. Nat Med 51(3):190-193. 26 AZUMA S, YADA Y, IMOKAWA G, TAZAKI S, SHINHO T, 1996 Skin-lightening cosmetics containing plant extracts and ascorbic acid or placenta extracts. Patent-Japan Kokai Tokyo Koho-08 208,451. 27 AMEER B, WEINTRAUB RA, JOHNSON JV, YOST RA, ROUSEFF RL, 1996 Flavonone absorption after naringin, hesperidin, and Citrus administration. Clin Pharmacol Ther 60(1):34-40. 28HARTMAN JG, LIMBIRD ILE, Eds., 1996 Goodman & Gilman las bases farmacológicas de la Terapéutica, 9^a edición. México, México: McGraw-Hill Editorial. p1670-1671. 29 HOU YC, HSIU SL, TSAO CW, WANG YH, CHAO PD, 2000 Acute intoxication of cyclosporin caused by coadministration of decoctions of the fruits of Citrus aurantium and the pericarps of Citrus grandis.Planta Med 66(7):653-655. 30 SATO A, 1989 Studies on anti-tumor activity of crude drugs. I. The effects of aqueous extracts of some crude drugs in short term screening test. Yakugaku Zasshi 109(6):407-423. 31 YAMAMOTO H, MIZUTANI T, NOMURA H, 1982 Studies on the mutagenicity of crude drug extracts. I. Yakugaku Zasshi 102(6):596-601. 32 MORIMOTO I, WATANABE F, OSAWA T, OKITSU T, KADA T, 1982 Mutagenicity screening of crude drugs with Bacillus subtilis REC-assay and Salmonella microsome reversion assay. Mutat Res 97(2):81-102. 33 CANIGUERAL S, VILA R, RISCO E, PEREZ F, PORTILLO A, FREIXA B, MILO B, VANACLOCHA B, RIOS JL, MORALES MA, ALONSO JR, BACHILLER LI, PERIS JB, STUBING G, 2002 Citrus aurantium. Vademecum de Fitoterapia, Editorial Masson, Barcelona, España, Jul.20,2002. URL: http://www.masson.es/book/fitoterapia.html 34 MARTINEZ MJ, MOREJON Z, LOPEZ M, BOUCOURT E, FUENTES V, MORON F, 2005 Clases tóxicas agudas (CTA) de una infusión de corteza de fruto fresco de Citrus aurantium L.Informe TRAMIL. Laboratorio Central de Farmacología, Facultad de Ciencias Médicas “Dr. Salvador Allende”, La Habana, Cuba. 35 MARTINEZ MJ, MOREJON Z, LOPEZ M, BOUCOURT E, FUENTES V, MORON F, 2005 Clases tóxicas agudas (CTA) de zumo de fruto fresco de Citrus aurantium L.Informe TRAMIL. Laboratorio Central de Farmacología, Facultad de Ciencias Médicas “Dr. Salvador Allende”, La Habana, Cuba. 36 GarcIa-GONZALEZ M, fallas LV, 2005 Toxicidad aguda dosis repetida, en ratones, del extracto acuoso (decocción) de las hojas frescas de Citrus aurantium . Informe TRAMIL.PRONAPLAMED. Depto de Fisiología, Escuela de Medicina, Universidad de Costa Rica, San Pedro, Costa Rica. 37 MORON FJ, MOREJON Z, GARCIA AI, LOPEZ M, BOUCOURT E, BACALLAO Y, FUENTES V, 2008 Acción analgésica de la decocción 30% de hojas frescas de Citrus aurantium L. (naranja agria) en ratones. Informe TRAMIL. Laboratorio Central de Farmacología, Facultad de Ciencias Médicas “Dr. Salvador Allende”, Ciudad de La Habana, Cuba. 38 PAZOS L, COTO T, CAIZA F, 2009 Irritación ocular, en conejos, del jugo fresco del fruto de Citrus aurantium. Informe TRAMIL. Laboratorio de Ensayos Biológicos, LEBi, Universidad de Costa Rica, San Pedro, Costa Rica. 39 LONGUEFOSSE JL, NOSSIN E, 1990-95 Enquête TRAMIL. Association pour la valorisation des plantes médicinales de la Caraïbe AVPMC, Fort de France, Martinique. 40 MOREJON Z, LOPEZ M, GARCIA MJ, BOUCOURT E, VICTORIA M, FUENTES V, MORON F, BOULOGNE I, ROBINEAU L, 2009 Encuesta TRAMIL preliminar a grupos de vecinos en los municipios 10 de Octubre, Lisa, Marianao, Habana del Este (Cojímar) en la Ciudad de la Habana. Laboratorio Central de Farmacología, Universidad de Ciencias Médicas de La Habana, Ciudad de La Habana, Cuba.
	Matricaria recutita (In territories with significant traditional TRAMIL use) Colombia : manzanilla Guatemala : manzanilla Honduras : manzanilla Significant uses found by the TRAMIL surveys entire plant, decoction, orally²	Recommandations Preparation and posology References	According to published and other information: Use for colic, diarrhea, stomach pain and expulsion of placenta is classified as REC, based on the significant traditional use documented in the TRAMIL surveys, and on available published scientific information. For diarrhea, the use of this plant can be considered complementary to oral re-hydration therapy. Should there be a notable worsening of the patient’s condition, or should the colic, diarrhea or stomach pain last more than 3 days, seek medical attention. The pollen is potentially allergenic and may induce reactions of hypersensitivity in susceptible individuals or those with prior allergy to Asteraceae (esp. ragweed and Chrysanthemum).		For menstrual pain and stomach pain: Prepare an infusion adding 250 mL (1 cup) of boiling water to 3 grams of dried flower. Cover pot, leave to settle for 5-10 minutes and filter. Drink one cup between meals, 3-4 times a day^32-33. There is no available information about preparation and dosage of the decoction of the entire plant, the infusion of the leaf, or the infusion of the leaf and flower, other than that referred to by traditional use.	1 RAUSCHERT S, 1974 Nomenklatorische Probleme in der Gattung Matricaria L. Folia Geobot Phytotax Praha 9:249-260. 2 LAGOS-WITTE S, 1988-89, 1996 Encuesta TRAMIL. Laboratorio de Histología Vegetal y Etnobotánica, Dep. de Biología, Universidad Nacional Autónoma de Honduras UNAH, Tegucigalpa, Honduras. 3 GOMEZ H, GAITAN R, DIAZ F, 2003 Encuesta TRAMIL (Norte del departamento de Bolívar). Grupo de Productos Naturales, Facultad de Ciencias Químicas y Farmacéuticas. Universidad de Cartagena, Cartagena de Indias, Colombia. 4 GIRON L, 1988 Encuesta TRAMIL (Costa atlántica). Centro Mesoamericano de Tecnología CEMAT, Guatemala, Guatemala. 5 FRANZ C, WICKEL I, 1980 Contribution to the heredity of bisaboloids in Chamomilla recutita. (abstract). Planta Med 39:287-288. 6 SALAMON I, 1992 Production of chamomile, Chamomilla recutita (L.) Rauschert, in Slovakia. J Herbs Spices Med Plants 1(1/2):37-45. 7 MANCHENO MN, 1987 La manzanilla dentro del plan terapéutico de tratamiento de la enfermedad diarreica aguda del Ministerio de Salud. Nicaragua. Rescate de la Medicina Popular Tradicional. 8 MERICLI AH, 1990 The lypophilic compounds of a Turkish Matricaria chamomilla variety with no chamazulene in the volatile oil. Int J Crude Drug Res 28(2):145-147. 9 TOPOLOV V, GABROLOV M, YANKOLOV J, 1983 Plantas medicinales and fitoterapia (Bilki and Bilcosvirane). Plovdiv, Bulgaria: Ed. Jristo G. Danov. 10 MORON F, FURONES J, PINEDO Z, 1996 Actividad espasmolítica del extracto fluído de Matricaria recutita (Manzanilla) en órganos aislados. Rev Cubana Plant Med 1(1):19-24. 11 CAMBAR P, 1992 Efectos broncopulmonares de los extractos acuosos de flores de Matricaria chamomilla L. (Manzanilla) en conejos. Informe TRAMIL. Unidad de Farmacología, Facultad de Ciencias Médicas, Universidad Nacional Autónoma de Honduras UNAH, Tegucigalpa, Honduras. 12 ABDUL-GHANI AS, EL-LATI SG, SACAAN AI, SULEIMAN MS, AMIN RM, 1987 Anticonvulsant effects of some Arab medicinal plants. Int J Crude Drug Res 25(1):39-43. 13 HOERHAMMER L, 1962 Flavone concentration of medicinal plants with regard to their spasmolytic action. Congr Sci Farm Conf Commun 21^st Pisa 1961(21):578-588. 14 JAKOVLEV V, ISAAC O, FLASKAMP E, 1983 Pharmacologische Untersuchungen von Kamillen-Inhaltsstoffen. VI. Untersuchungen zur antiphlogistiche Wirkung von Chamazulen und Matricin. Planta Med 49:67-73. 15 YAMAZAKI M, SHIROTA H, 1981 Application of experimental stress ulcer test in mice for the survey of neurotropic naturally occurring drug materials. Shoyakugaku Zasshi 35:96-102. 16 GERSHEBIN LL, 1977 Regeneration of rat liver in the presence of essential oils and their components. Food Cosmet Toxicol 15(3):173-182. 17 ITOKAWA H, MIHASHI S, WATANABE K, NATSUMOTO H, HAMANAKA T, 1983 Studies on the constituents of crude drugs having inhibitory activity against contraction of the ileum caused by histamine or barium chloride (I). Screening test for the activity of commercially available crude drugs and the related plant materials. Shoyakugaku Zasshi 37(3):223-228. 18 LESLIE GB, 1978 A pharmacometric evaluation of nine bio-strath herbal remedies. Medita 8(10):3-19. 19 SZELENYI I, ISSAC O, THIEMER K, 1979 Pharmakologische Untersuchungen von Kamillen-inhaltsstoffen. III. Tierexperimentelle Untersuchungen uber die ulkusprotektive Wirkung der Kamille. Planta Med 35:218-227. 20 SHIPOCHLIEV T, 1981 Uterotonic action of extract from a group of medicinal plants. Vett Med Nauki 18(4):94-98. 21 ACHTERRATH-TUCKERMANN U, KUNDE R, FLASKAMP E, ISAAC O, THIEMER K, 1980 Pharmacological investigations with compounds of chamomile. V. Investigations on the spasmolytic effect of compounds of chamomile and Kamillosan on the isolated guinea pig ileum. Planta Med 39(1):38-50. 22 AGGAG ME, YOUSEF RT, 1972 Study of antimicrobial activity of chamomile oil. Planta Med 22(2):140-144. 23 MANN C, STABA E, 1986 The chemistry, pharmacology and commercial formulations of chamomile. In: Herbs, spices and medicinal plants; recent advances in botany, horticulture and pharmacology. Phoenix, USA: Oryxpress 1:235-280. 24 ISAAC O, 1979 Pharmacological investigations with compounds of chamomile I. On the pharmacology of alfa-bisabolol and bisabolol oxides (review). Planta Med 35:118-124. 25 JAKOVLEV V, SCHLICHTEGROLL A, 1969 Antiinflammatory activity of (-)-alpha-bisabolol, an essential component of chamomille oil. Arzneim-Forsch 19:615. 26 AL-HINDAWI M, AL-DEEN I, NABI M, ISMAIL M, 1989 Antiinflamatory activity of some Iraqi plants using intact rats. J Ethnopharmacol 26(2):163-168. 27 LESLIE G, SALMON G, 1979 Repeated dose toxicity studies and reproductive studies on nine bio-strath herbal remedies. Swiss Med 1(1/2):1-3. 28 BENNER MH, LEE HJ, 1973 Anaphylactic reaction to chamomille tea. J Allergy Clin Immunol 52(5):307-308. 29 LEWIS R, TATKEN R, (Eds.), 1980 Registry of toxic effects of chemical substances. Vol. 1. Cincinnati, USA: Nat. Instit. Occupational Health. 30 OPDYKE D, 1974 Monographs on fragrance raw materials. Chamomile oil German and Roman. Food Cosmet Toxicol 12(Suppl.):851-853. 31 ANON (Select Committee on GRAS Substances), 1976 GRAS status of foods and food additives. Washington, USA: Food and Drug Administration, Department of Health and Human Services, Office of the Federal Register National Archives and Records Administration 41, 38644. 32 WICHTL M, 1994 Herbal drugs and phytopharmaceuticals. Stuttgart, Germany: Medpharm GmbH Scientific Publisher. 33 GIRON L, CACERES A, FREIRE V, ALONZO A, SALVADOR L, 1995 Folleto informativo sobre algunas plantas medicinales comúnmente utilizadas por la población Garifuna de Livingston. Guatemala, Guatemala: Programa TRAMIL-Centroamérica/enda-caribe/CONAPLAMED/FARMAYA/CIID. p37. 34 MARTINEZ MJ, MOREJON Z, LOPEZ M, BOUCOURT E, MORON F, 2005 Clases tóxicas agudas (CTA) de decocción de flor seca de Matricaria recutita L. Informe TRAMIL. Laboratorio Central de Farmacología, Facultad de Ciencias Médicas “Dr. Salvador Allende”, La Habana, Cuba. 35 LOPEZ M, MARTINEZ MJ, MOREJON Z, BOUCOURT E, FERRADA C, FUENTES V, MORON F, 2005 Irritabilidad dérmica primaria de una decocción de flor seca de Matricaria recutita L. Informe TRAMIL. Laboratorio Central de Farmacología, Facultad de Medicina “Dr. Salvador Allende”, Cerro, C. Habana, Cuba. 36 GarcIa-GONZÁLEZ M, BolaÑos An, arguedas cr, 2005 Efecto analgésico en ratas, por vía oral,del extracto acuoso (decocción) de la planta entera sin flor de Matricaria recutita dosis única. Informe TRAMIL.PRONAPLAMED. Depto de Fisiología, Escuela de Medicina, Universidad de Costa Rica, San Pedro, Costa Rica. 37 GarcIa-GONZÁLEZ M, Arguedas R, y Fernández A, 2005 Efecto antiinflamatorio en ratas, por vía oral, del extracto acuoso (decocción) de la planta entera sin flor de Matricaria recutita dosis única. Informe TRAMIL.PRONAPLAMED. Depto de Fisiología, Escuela de Medicina, Universidad de Costa Rica, San Pedro, Costa Rica.
	Tanacetum parthenium (In territories with significant traditional TRAMIL use) Guatemala : altamiza Significant uses found by the TRAMIL surveys leaf, infusion, orally¹	Recommandations Preparation and posology References	According to published and other information: Uses for stomach pain are classified as REC, based on the significant traditional use (OMS/WHO)³ documented in the TRAMIL surveys. Should there be a notable worsening of the patient’s condition, or should symptoms persist for more than 3 days, seek medical attention. Due to the risks of interaction with anticoagulants, the leaf decoction should not be ingested by patients treated with anticoagulants⁴. Not for use by pregnant women as it may cause abortion. Not for use during lactation, or by children under 5 years old.		This plant is used as aperitif¹⁹. For stomach pain: Add 250 mL of boiling water to 3 grams of leaf and fresh flowers. Cover pot, leave to settle for 5-10 minutes and filter. Drink 1 cup 3 times a day²¹. Any medicinal preparation must be preserved cold and used within the 24 hours. The herb is not good-tasting and has some adverse effects. The recommendation is to take only occasionally, using standardized products⁴.	2 GIRON L, 1988 Encuesta TRAMIL (Costa atlántica). Centro Mesoamericano de Tecnología CEMAT, Guatemala, Guatemala. 3 WHO, 1991 Guidelines for the assessment of herbal medicines. WHO/TRM/91.4. Programme on Traditional Medicines, WHO, Geneva, Switzerland. 4 ALONSO JR, 1998 Tratado de fitomedicina. Bases clínicas y farmacológicas. Buenos Aires, Argentina: Ed. ISIS S.R.L. p910. 5 WILLIAMS CA, HOULT JRS, HARBORNE JB, GREENHAM J, EAGLES J, 1995 A biologically active lipophilic flavonol from Tanacetum parthenium. Phytochemistry 38(1):267-270. 6 DOLMAN DM, KNIGHT DW, SALAN U, TOPLIS D, 1992 A quantitative method for the estimation of parthenolide and other sesquiterpene lactones containing alpha- methylene-butyrolactone functions present in feverfew, Tanacetum parthenium. Phytochem Anal 3(1):26-31. 7 BARSBY RW, SALAN U, KNIGHT DW, HOULT JR, 1993 Feverfew and vascular smooth muscle: extracts from fresh and dried plants show opposing pharmacological profiles, dependent upon sesquiterpene lactone content. Planta Med 59(1):20-25. 8 WAGNER H, FESSLER B, LOTTER H, WRAY V, 1988 New chlorine-containing sesquiterpene lactones from Chrysanthemum parthenium. Planta Med 54(2):171-172. 9 BEGLEY MJ, HEWLETT MJ, KNIGHT D, 1989 Revised structures for guaianolide alpha-methylenebutyrolactones from feverfew. Phytochemistry 28(3):940-943. 10 SCHULTZ BI, BANTHORPE DV, BROWN GD, JANES JF, MARR IM, 1990 Parthenolide and other volatiles in the flowerheads of Tanacetum parthenium (L.). Flavour Fragrance J 5:183-186. 11 PLOUVIER V, 1985 Occurrence and distribution of syringoside, calycanthoside and similar coumarinic glycosides in several botanical groups. CR Acad Sci Ser III 301(4):117-120. 12 LOESCHE W, GROENEWEGEN WA, KRAUSE S, SPANGENBERG P, HEPTINSTALL S, 1988 Effects of an extract of feverfew (Tanacetum parthenium) on arachidonic acid metabolism in human blood platelets. Biomed Biochim Acta 47(10-11):S241-S243 13 HEPTINSTALL S, GROENEWEGEN WA, SPANGENBERG P, LOSCHE W, 1988 Inhibition of platelet behaviour by feverfew: A mechanism of action involving sulphydryl groups. Folia Haematol (Leipzig) 115(4):447-449. 14 GROENEWEGEN WA HEPTINSTALL S, 1990 A comparison of the effects of an extract of feverfew and parthenolide, a component of feverfew, on human platelet activity in vitro. J Pharm Pharmacol 42(8):553-557. 15 BHAKUNI DS, BITTNER M, MARTICORENA C, SILVA M, WELDT E, MELO ME, ZEMELMAN R, 1974 Screening of Chilean plants for antimicrobial activity. Llyodia 37(4):621-632. 16 CACERES A, SAMAYOA B, 1989 Tamizaje de la actividad antibacteriana de plantas usadas en Guatemala para el tratamiento de afecciones gastrointestinales. Guatemala: Dirección General de Investigaciones, Univers. San Carlos (DIGI-USAC). 17 BALDWIN CA, ANDERSON LA, PHILLIPSON JD, 1987 What pharmacists should know about feverfew. Pharm J 239:237-238. 18 ANON, 1994 Fitoterapia. Vademecum de prescripción de plantas medicinales. Asociación Española de Médicos Naturistas y Colegio Oficial de farmacéuticos de Vizcaya. Tanacetum parthenium 2da. Ed. España: CITA Publicaciones y Documentaciones. p231-232. 19 ANON, 1996 British Herbal Pharmacopoeia, Tanacetum parthenium.4^th ed. Bournemouth, Great Britain: British Herbal Medicine Association. p81-82. 20 Newall C, Anderson L, PhillIpson D, 1996 Herbal medicines: A guide for health care professionals. The Pharmaceutical Press, London, England. p121. 21 GIRON L, CACERES A, FREIRE V, ALONZO A, SALVADOR L, 1995 Folleto informativo sobre algunas plantas comúnmente utilizadas por la población Garífuna de Livingston, Guatemala, Guatemala, p13.