abscess | TRAMIL

	Cissus verticillata (In territories with significant traditional TRAMIL use) Dominican Republic : bejuco caro Haiti : lyann mòl Significant uses found by the TRAMIL surveys leaf, slightly heated, applied locally^1-2	Recommandations Preparation and posology References	According to published and other information: The topical use for abscess, ganglionar inflammation and boils is classified as REC, based on the significant traditional use documented in the TRAMIL surveys, and skin toxicity studies. For topical application, strict hygiene measures should be observed in order to avoid contamination or additional infection. Should there be a notable worsening of the patient’s condition, or should the abscess or boils last more than 5 days, seek medical attention. Oral administration for cold, cough and influenza is classified as REC, based on the significant traditional use documented in the TRAMIL surveys and toxicity studies. Not for use by women during pregnancy, during lactation or by children under 5 years old.		For abscess, ganglionar inflammation and boils: Wash injury with boiled water and soap. Apply the washed and crushed leaf in sufficient quantity to the affected area. Cover the injury with a dressing or clean cloth. Replace every 12 hours. For colds, cough and influenza: There is no available information establishing a means of preparation and dosage other than that referred to by traditional use.	1 WENIGER B, ROUZIER M, 1986 Enquête TRAMIL. Service Oecuménique d'Entraide SOE, Port au Prince, Haïti. 2 GERMOSEN-ROBINEAU L, GERONIMO M, AMPARO C, 1984 Encuesta TRAMIL. enda-caribe, Santo Domingo, Rep. Dominicana. 3 WENIGER B, SAVARY H, DAGUIHL R, 1984 Tri phytochimique de plantes de la liste TRAMIL. Laboratoire de chimie des substances naturelles, Faculté de Médecine et de Pharmacie, Université d'Etat d'Haïti, Port au Prince, Haïti. 4 PINEDA M, 1990 Fitoquímica de algunas plantas TRAMIL. Laboratorio enda-caribe, Santo Domingo, Rep. Dominicana. 5 STANDLEY PC, 1937 The flora of Costa Rica, Pt. I. Bot Serv Field Mus Nat Hist 18(391):398. 6 TOLEDO MCF, REYES FGR, IADEROZA M, FRANCIS FJ, DRAETTA IS, 1983 Anthocyanins from anil trepador (Cissus sicyoides Linn.) J Food Sci 48(4):1368-1369. 7 MARTINEZ MJ, LOPEZ M, BOUCOURT E, FUENTES V, MORON F, 2002 Evaluación de la actividad antiestafilocóccica de Cissus verticillata. Informe TRAMIL.Laboratorio Central de Farmacología, Facultad de Ciencias Médicas "Dr. Salvador Allende", La Habana, Cuba. 8 LE GRAND A, WONDERGEM PA, 1986 Activités antimicrobiennes et études bibliographiques de la toxicologie de dix plantes médicinales de la Caraïbe. Rapport TRAMIL. Dép. de Pharmacognosie, Universités de Groningen & Leyden, Hollande. 9 CAMBAR P, 1992 Efecto de los extractos acuosos de Cissus verticillata L. Informe TRAMIL. Unidad de Farmacología, Facultad de Ciencias Médicas, Universidad Nacional de Honduras UNAH, Tegucigalpa, Honduras. 10 GUARDARRAMA I, FRANCO A, ROMERO M, 1992 Estudio preliminar de las propiedades antiserotonínicas del Cissus sicyoides (Bejuco ubí). Informe TRAMIL. Instituto Superior de Ciencias Médicas, Santa Clara, Cuba. TRAMIL VI, Basse Terre, Guadeloupe, UAG/enda-caribe. 11 FENG PC, HAYNES LJ, MAGNUS KE, PLIMMER JR, 1964 Pharmacological screening of some West Indian medicinal plants. J Pharm Pharmacol 16:115-117. 12 JIU J, 1966 A survey of some medicinal plants of Mexico for selected biological activities. Lloydia 29:250-259. 13 GARCIA MD, QUILEZ AM, SAENZ MT, MARTINEZ DOMINGUEZ ME, DE LA PUERTA R, 2000. Anti-inflammatory activity of Agave intermixta Trel. and Cissus sicyoides L., species used in South Caribbean traditional medicine. J Ethnopharmacol 71(3): 395-400. 14 MARTINEZ MJ, LOPEZ M, BOUCOURT E, BETANCOURT J, FUENTES V, MORON F, 2002. Irritabilidad dérmica primaria de Cissus verticillata. Informe TRAMIL. Laboratorio Central de Farmacología, Facultad de Ciencias Médicas "Dr. Salvador Allende", La Habana, Cuba. 15 MARTINEZ MJ, LOPEZ M, BOUCOURT E, BETANCOURT J, FUENTES V, MORON F, 2002. Toxicidad aguda tópica de Cissus verticillata. Informe TRAMIL. Laboratorio Central de Farmacología, Facultad de Ciencias Médicas "Dr. Salvador Allende", La Habana, Cuba.
	Curcuma longa (In territories with significant traditional TRAMIL use) Haiti : safran Haiti : curcuma Saint Lucia : tjitjima Saint Lucia : turmeric Saint Lucia : Indian saffron Significant uses found by the TRAMIL surveys rhizome, decoction, orally¹	Recommandations Preparation and posology References	According to published and other information: Use for jaundice and hepatic disorders is classified as REC, based on the significant traditional use documented in the TRAMIL surveys, and on available published scientific information. Due to the health risks involved with jaundice and hepatic disorders, an initial medical evaluation is recommended. The use of this resource can be considered complementary to medical treatment, unless it is contraindicated. Should there be a notable worsening of the patient’s condition, or should the hepatic disorder last more than 5 days, or 3 days in children under 5 years, seek medical attention. Not for use by women intending to become pregnant, during pregnancy, during lactation or by children under 3 years old. Use for abscess is classified as REC, based on the significant traditional use (WHO)⁴ documented in the TRAMIL surveys. Not for use in patients with obstructions in the bile-conducting structures, such as stones, unless under supervision of a physician, nor in people with a record of hypersensitivity to the plant^4-5. Rhizome powder can cause reactions in case of contact with the skin.		The rhizome of Curcuma longa is widely used for human consumption and is an industrial source of essential oil. For abscess and jaundice : Prepare a decoction with 20 grams (4 teaspoonfuls) of rhizome in 1 liter (4 cups) of water, and boil for at least 10 minutes in a covered pot. Leave to cool down, and drink 1 cup 3-4 times a day. For jaundice and hepatic disorders: Grind 20 grams (4 teaspoonfuls) of rhizome and add to 1 liter (4 cups) of boiled water. Let the preparation settle for 12 hours. Filter and drink in several portions within the following 12 hours⁴⁷.	1 JEAN-PIERRE L, 1988 TRAMIL survey. St. Lucia National Herbarium, Castries, St. Lucia. 2 WENIGER B, ROUZIER M, 1986 Enquête TRAMIL. Service Oecuménique d'Entraide SOE, Port au Prince, Haïti. 3 WHO, 1991 Pautas para la evaluación de medicamentos herbarios WHO/TRM/91.4 (original inglés). Programa de Medicina Tradicional, OMS, Ginebra, Suiza. 4 WHO, 2002 WHO monographs on selected medicinal plants. Volume 1. Feb.28,2003, URL: http://www.who.int/medicines/library/trm/medicinalplants/pdf/259to266.pdf 5 PDR^® for Herbal Medicines, 2003 Feb.28,2003. URL: http://www.mdcc.edu/medical/library/catalog2.htm 6 OGBEIDE ON, EDUAVEGUAVOEN OI, PARVEZ M, 1985 Identification of 2-(hydroxymethyl) anthraquinone in Curcuma domestica. Pak J Sci 37(1/4):15-17. 7 SU HCF, HORVAT R, JILANI G, 1982 Isolation, purification, and characterization of insect repellents from Curcuma longa L. J Agric Food Chem 30:290-292. 8 OHSHIRO M, KUROYANAGI M, UENO A, 1990 Structures of sesquiterpenes from Curcuma longa. Phytochemistry 29(7):2201-2205. 9 CHEN YH, YU JG, FANG HJ, 1983 Studies on Chinese Curcuma. III. Comparison of the volatile oil and phenolic constituents from the rhizome and the tuber of Cucurma longa. Chung Yao T'ung Pao 8(1):27-29. 10 MOON CK, PARK NS, KOH SK, 1976 Studies on the lipid components of Curcuma longa. I. The composition of fatty acids and sterols. Soul Taehakkyo Yakhak Nonmunjip 1:132. 11 YASUDA K, TSUDA T, SHIMIZU H, SUGAYA A, 1988 Multiplication of Curcuma species by tissue culture. Planta Med 54(1):75-79. 12 SCHULTZ JM, HERRMANN K, 1980 Occurrence of hydroxybenzoic acids and hydroxycinnamic acid in spices. IV. Phenolics of spices. Z Lebensm-Unters Forsch 171:193-199. 13 PARK SN, BOO YC, 1991 Cell protection from damage by active oxygen with curcuminoids. Patent-Fr Demande-2,655,054. 14 TODA S, MIYASE T, ARICHI H, TANIZAWA H, TAKINO Y, 1985 Natural antioxidants. III. Antioxidative components isolated from rhizome of Curcuma longa L. Chem Pharm Bull 33(4):1725-1728. 15 JENTZSCH K, SPIEGL P, KAMITZ R, 1970 Qualitative and quantitative studies of curcuma dyes in different Zingiberaceae drugs. 2. Quantitative studies. Sci Pharm 38:50. 16 KARIG F, 1975 Rapid identification of curcuma rhizomes with the tas (thermomicroseparation and application) process. Dtsch Apoth Ztg 115:325. 17 GONDA R, TOMODA M, TAKADA K, OHARA N, SHIMIZU N, 1992 The core structure of ukonan A, a phagocytosis-activating polysaccharide from the rhizome of Curcuma longa, and immunological activities of degradation products. Chem Pharm Bull 40(4):990-993. 18 WOO WS, CHI HJ, YUN HS, WOO LK, 1977 Phytochemical screening of Korean medicinal plants (II). Korean J Pharmacog 8:103-108. 19 DE SOUSA M, Matos ME, Matos FJ, MACHADO MI, CRAVEIRO AA,1991 Constituintes químicos ativos de plantas medicinais Brasileiras.Laboratorio de produtos naturais, Fortaleza, Brasil: Ceará Edições UFC. 20 YANG M, DONG X, TANG Y, 1984 Studies of the chemical constituents of common turmeric (Curcuma longa). Chung Ts'ao Yao 15(5):197-198. 19 ZHAO DY, YANG MK, 1986 Separation and determination of cucurminoids in Curcuma longa L. and its preparation by HPLC. Yao Hsueh Pao 21(5):382-385. 22 KISO Y, SUZUKI Y, WATANABE N, OSHIMA Y, HIKINO H, 1983 Antihepatotoxic principles of Curcuma longa rhizomes. Planta Med 49(3):185-187. 23 GONDA R, TOMODA M, SHIMIZU N, KANARI M, 1990 Characterization of polysaccharides having activity on the reticuloendothelial system from the rhizome of Curcuma longa. Chem Pharm Bull Tokyo 38(2):482-486. 24 DUKE JA, ATCHLEY AA, 1986 Handbook of proximate analysis tables of higher plants. Boca Raton, USA: CRC Press. p56. 25 SOLIS PN, RODRIGUEZ N, ESPINOSA A, GUPTA MP, 2004 Estudio antimicrobiano de algunas plantas TRAMIL con usos en Martinica. Informe TRAMIL. Centro de Investigaciones Farmacognósticas de la Flora Panameña CIFLORPAN, Facultad de Farmacia, Universidad de Panamá, Panamá, Panamá. 26 JOYEUX M, FLEURENTIN J, DORFMAN P, MONTIER F, 1988 Recherche d'une activité hépatotrope et antiradicalaire de plantes médicinales de la caraïbe. Rapport TRAMIL. Laboratoire de pharmacognosie, Centre des Sciences pour l'Environnement, Metz, France. 27 CHANG IM, WOO WS, 1980 Screening of Korean medicinal plants for antitumor activity. Arch Pharm Res 3(2):75-78. 28 KOSUGE T, YOKOTA M, SUGIYAMA K, YAMAMOTO T, NI MY, YAN SC, 1985 Studies of antitumor activities and antitumor principles of Chinese herbs. Yakugaku Zasshi 105(8):791-795. 29 ITOKAWA H, 1988 Research on antineoplastic drugs from natural sources, especially from higher plants. Yakugaku Zasshi108(9):824-841. 30 SRIVASTAVA KC, 1989 Extracts from two frequently consumed spices cumin (Cuminum cyminum) and turmeric (Curcuma longa) inhibit platelet aggregation and alter eicosanoid biosynthesis in human blood platelets. Prostaglandins Leukotr Essent Fatty Acids37(1):57-64. 31 DIXIT VP, JAIN P, JOSHI SC, 1988 Hypolipidaemic effects of Curcuma longa L. & Nardostachys jatamansi in triton-induced hyperlipidaemic rats. Indian J Physiol Pharmacol 32(4):299-304. 32 DONATUS IA, SARDJOKO, VERMEULEN NPE, 1990 Cytotoxic and cytoprotective activities of curcumin. Effects on paracetamol induced cytotoxicity, lipid peroxidation and glutathione depletion in rat hepatocytes. Biochem Pharmacol 39(12):1869-1875. 33 AMMON HP, WAHL MA, 1991 Pharmacology ofCurcuma longa. Planta Med57(1):1-7. 34 DUKE JA, 1992 Handbook of biologically active phytochemicals and their bioactivities. Boca Raton, USA: CRC Press. 35 DUKE JA, 1992 Handbook of phytochemical constituents of GRAS Herbs and other economic plants. Boca Raton, USA: CRC Press. 36 KINOSHITA G, NAKAMURA F, MARUYAMA T, 1986 Immunological studies on polysaccharide fraction of crude drugs. Shoyakugaku Zasshi 40(3):325-332. 37 PINKAS M, BEZANGER-BEAUQUESNE L, 1986 Les plantes dans la thérapeutique moderne.Paris, France: 2 éd. Ed. Maloine. 38 KOSUGE T, ISHIDA H, YAMAZAKI H, 1985 Studies on active substances in the herbs used for oketsu ("stagnant blood") in Chinese medicine III. On the anticoagulative principles in curcumae rhizoma. Chem Pharm Bulll (Tokyo) 33(4):1499-1502. 39 BLANCK W,1990 Processes for the preparation of medicinal compositions, compositions obtained by these processes and use thereof for the preparation of medicines against viral hepatitis B and acquired immunodeficiency syndrome. World Intellectual Property Org./U.S.Patent & Trademark Office, Bibliographic File of Published PCT Internat. Applications. Jan.1983 to Dec.1989; Prototype Jun.1990. Int. Pub. No. 8805304. 40 SONI KB, LAHIRI M, CHACKRADEO P, BHIDE SV, KUTTAN R, 1997 Protective effect of food additives on aflatoxin-induced mutagenicity and hepatocarcinogenicity. Cancer Lett 115(2):129-133. 41 AZUINE MA, KAYAL JJ, BHIDE SV, 1992 Protective role of aqueous turmeric extract against mutagenicity of direct-acting carcinogens as well as benzo [alpha] pyrene-induced genotoxicity and carcinogenicity. J Cancer Res Clin Oncol 118(6):447-52. 42 YEGNANARAYANA M, SARAF AP, BALWANI JH, 1976 Comparison of anti-inflammatory effect of various extracts of Curcuma longa. Indian J Med Res64(4):601-608. 43 POLASA K, SESIKARAN B, KRISHNA TP, KRISHNASWAMY K, 1991 Turmeric (Curcuma longa) - induced reduction in urinary mutagens. Food Chem Toxicol 29(10):699-706. 44 QURESHI S, SHAH AH, AGEEL AM, 1992 Toxicity studies on Alpinia galanga and Curcuma longa. Planta Med 58(2):124-127. 45 VIJAYALAXMI, 1980 Genetic effect of turmeric and curcumin in mice and rats. Mut Res 79:125-132. 46 KAMBOJ VP, 1988 A review of Indian medicinal plants with interceptive activity. Indian J Med Res 4:336-355. 47 SEETHARAM KA, PASRICHA JS, 1987 Condiments and contact dermatitis of the finger-tips. Indian J Dermatol Venereol Leprol 53(6):325-328. 48 ALBORNOZ A, 1993 Medicina Tradicional Herbaria. Caracas, Venezuela: Editorial Instituto Farmacoterápico Latino S.A. p227. 49 PAZOS L, COTO T, GONZALEZ S, 2006 Toxicidad oral subcrónica, dosis repetida, en ratón, del extracto de rizoma fresco de Curcuma longa. Informe TRAMIL. Laboratorio de Ensayos Biológicos, LEBi, Universidad de Costa Rica, San Pedro, Costa Rica.
	Dioscorea bulbifera (In territories with significant traditional TRAMIL use) Haiti : masoko Significant uses found by the TRAMIL surveys grated tuber, applied locally¹	Recommandations Preparation and posology References	According to published and other information: Use for abscess and ganglionar inflammation is classified as REC, based on the significant traditional use (OMS/WHO)⁴ documented in the TRAMIL surveys. For topical application, strict hygiene measures should be observed in order to avoid contamination or additional infection.		For abscess and ganglionar inflammation: There is no available information establishing a means of preparation and dosage other than that referred to by traditional use.	1 WENIGER B, ROUZIER M, 1986 Enquête TRAMIL. Service Oecuménique d'Entraide SOE, Port au Prince, Haïti. 2 WHO, 1991 Guidelines for the assessment of herbal medicines. WHO/TRM/91.4. Programme on Traditional Medicines, WHO, Geneva, Switzerland. 3 IDA Y, KUBO S, FUJITA M, KOMORI T, KAWASAKI T, 1978 Furanoid diterpenes from plants of the Discoreaceae. V. Structure of diosbulbin D, E, F, G & H. Justus Liebigs Ann Chem. p818. 4 IDA Y, NODA W, KUBO S, KOMORI T, KAWASAKI T, 1978 Furanoid norditerpenes from Dioscorea plants. VII. Structures of diosbulbinosides D & F. Chem Pharm Bull 26:435. 5 MURRAY R, JORGE KHAN N, SHAHJAHAN M, QUAISUDDIN M, 1984 Diosbulbin D and 8-epidiosbulbin E acetate, norclerodane diterpenoids from Dioscorea bulbifera tubers. Phytochemistry 23(3):623-625. 6 KHAN N, NUR-E-KAMAL M, SHAHJAHAN M, HASAN C, 1986 Chemical investigation of tubers of Dioscorea bulbifera l. Variety sativa. Khaka Univ Stud Part B 34(1):111-113. 7 GUPTA D, SINGH J, 1989 Hydroxy-acetophenone derivatives from Dioscorea bulbifera. Phytochemistry 28(3):947-949. 8 IRELAND C, SCHWABE W, GOURSEY D, 1981 The occurrence of batatasins in the Dioscoreaceae. Phytochemistry 20:1569-1571. 9 RAGHUNADAN K, JOLLY C, 1987 Starch from Dioscorea bulbifera. Indian J Pharm Sci 49(6):233-236. 10 DUKE JA, ATCHLEY AA, 1986 Handbook of proximate analysis tables of higher plants. Boca Raton, USA: CRC Press. p64. 11 ABDEL-AZIZ A, BRAIN K, BASHIR A, 1990 Screening of Sudanese plants for molluscicidal activity and identification of leaves ofTacca leontopetaloides L. O. Ktze (Taccaceae), as a potential new exploitable resource. Phytother Res 4(2):62-65. 12 CHEN L, 1988 Treatment of 11 cases of malignant lymphoma. Zhejiang J Trad Chin Med 23(8):365-366. 13 SATO A, 1989 Studies on anti-tumor activity of crude drugs. I. The effects of aqueous extracts of some crude drugs in short term screening test. Yakugaku Zasshi 109(6):407-423. 14 YAN Z, 1989 Adverse reactions to Chinese drugs, 384 cases. Chin Pharmaceut J 24(3):166-169.